Why is granulation wet?

Wet granulation reduces the level of dust present during manufacturing process thereby reducing the incidence of cross-contamination and risk to workers. 9. Wet granulation reduces the amount of air entrapment thereby increasing powder compressibility.

How does wet granulation work?

Wet Granulation: The process of adding a liquid solution to powders involves the massing of a mix of dry primary powder particles using a granulating fluid. The fluid contains a solvent that must be volatile, so that it can be removed by drying, and be non-toxic.

What is moist granulation?

Moist granulation is the process of adding a granulating fluid, such as water or ethanol, etc. to dry powdered materials to create a mixture that is then forced into a granulating extrusion cylinder where the material is compacted and cut off by a scraper to form larger size granules.

Is wet or dry granulation better?

Importance. Dry Granulation: Dry granulation is required when producing tablets from highly moisture and heat sensitive compounds. Wet Granulation: Wet granulation is required to avoid the destruction of active components in the powder.

What are the stages of wet granulation?

In summary, wet granulation process involves 4 main stages – preparing material, wetting powder, nucleation and drying.

What are the advantages of wet granulation over dry granulation?

1 Introduction

Wet granulation
Advantages • More uniform mixing than dry granulation • More binding in less quantity of binder • Better content uniformity • Suitable for very low to very high drug content • Reduces sticking of blend to compression tooling

Which mixer is used for wet granulation?

Common types of wet granulation equipment used in the pharmaceutical industry include mixer granulators where the powder is agitated by a large impeller at the base of mixer bowl, or fluid bed granulators where air is blown upwards through the powder to agitate and fluidize the particles.

What are problems of granulation?

Nevertheless, granulation poses numerous challenges due to high quality requirement of the formed granules in terms of content uniformity and physicochemical properties such as granule size, bulk density, porosity, hardness, moisture, compressibility, etc. together with physical and chemical stability of the drug.

Why is granulation important?

Granulation is a key processing step in the production of many solid dosage drugs. It is often necessary to convert powdered drug formulations into a physical form that has improved flow and compaction characteristics to produce tablets with uniform content and consistent hardness and other properties.