Answer. Adverse effects of the NRTI class include mitochondrial toxicities (e.g., lactic acidosis, pancreatitis, peripheral neuropathy, hepatic steatosis, lipoatrophy).
What are the side effects of NRTIs?
NRTIs and Side Effects
- Stomach problems.
- Trouble sleeping.
What is nucleoside reverse transcriptase inhibitors NRTIs?
The nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) were the first class of antiretroviral drugs to be approved by the FDA. NRTIs are taken as prodrugs and must be taken into the host cell and phosphorylated before they become active. Once inside the host cell, cellular kinases will activate the drug.
What do NRTIs do?
NRTIs are one of 6 classes of antiretroviral drugs (ARVs) used to treat HIV as part of antiretroviral therapy (ART). ARVs interfere with the ability of a virus to multiply or reproduce. To treat HIV, NRTIs work by blocking an enzyme HIV needs to make copies of itself.
Why do NRTIs cause lactic acidosis?
Hepatic steatosis and lactic acidosis are thought to be caused by nucleoside reverse-transcriptase inhibitor (NRTI)–associated mitochondrial toxicity that results in inhibition of mitochondrial DNA γ-polymerase, which, in turn, impairs synthesis of mitochondrial enzymes that generate adenosine triphosphate .
What is a common concern when taking epzicom?
Although rare, NRTIs including Epzicom can cause a life-threatening liver problem called lactic acidosis with hepatic steatosis. Most of the cases have been in women. Symptoms include appetite loss, stomach pain, muscle pain, fast and shallow breathing, extreme tiredness, and sudden weakness.
Which one drug is NRTIs?
List of Nucleoside reverse transcriptase inhibitors (NRTIs):
|Drug Name||Avg. Rating||Reviews|
|Vemlidy (Pro) Generic name: tenofovir alafenamide||8.0||1 review|
|Epivir-HBV (Pro) Generic name: lamivudine||10||1 review|
|Baraclude (Pro) Generic name: entecavir||10||1 review|
|Ziagen (Pro) Generic name: abacavir||8.0||No reviews|