When should FFP be given?

Fresh frozen plasma should be administered immediately after thawing. If fresh frozen plasma is not given immediately after thawing, it should be stored at 1 to 6 Celsius. If the thawed fresh frozen plasma is not used in 24 hours, it should be discarded.

When would you give fresh frozen plasma?

Fresh frozen plasma (FFP) is used for patients with a coagulopathy who are bleeding or at risk of bleeding, and where a specific therapy or factor concentrate is not appropriate or unavailable.

When should you not give FFP?

Do Not Do Recommendation

Only consider fresh frozen plasma transfusion for patients with clinically significant bleeding but without major haemorrhage if they have abnormal coagulation test results (for example, prothrombin time ratio or activated partial thromboplastin time ratio above 1.5).

When is a plasma transfusion needed?

Plasma Transfusions

Plasma is the liquid part of the body’s blood. It contains important proteins and other substances crucial to one’s overall health. Plasma transfusions are used for patients with liver failure, severe infections, and serious burns.

What are the indications for FFP transfusion?

Fresh frozen plasma (FFP) is given primarily for three indications: to prevent bleeding (prophylaxis), stop bleeding (therapeutic) or for plasma exchange. Prophylactic transfusions are mainly used prior to surgery or invasive procedures.

When do you give FFP vs cryoprecipitate?

FFP is indicated when a patient has MULTIPLE factor deficiencies and is BLEEDING. Note that FFP SHOULD NEVER be used as a plasma expander. Cryoprecipitate (cryo) contains a concentrated subset of FFP components including fibrinogen, factor VIII coagulant, vonWillebrand factor, and factor XIII.

Why do we give FFP for high INR?

In the latter settings the interlaboratory agreement may be poor and the bleeding risks poorly correlated with INR. The purpose of FFP transfusion is to lower the risk of bleeding in patients with coagulopathy. However, studies have found no difference in bleeding events in patients receiving FFP compared to those not.

When is cryoprecipitate given?

Cryo is used to prevent or control bleeding in people whose own blood does not clot properly. This includes patients with serious but rare hereditary conditions such as Hemophilia A (who lack factor VIII) and von Willebrand disease (who lack von Willebrand factor).

When do you give platelets vs FFP?

Fresh frozen plasma infusion can be used for reversal of anticoagulant effects. Platelet transfusion is indicated to prevent hemorrhage in patients with thrombocytopenia or platelet function defects.

What is the INR of FFP?

A unit of FFP has a volume of 175 to 250 mL and an inherent INR of up to 1.3.

Why is plasma given?

Plasma is commonly given to trauma, burn and shock patients, as well as people with severe liver disease or multiple clotting factor deficiencies. It helps boost the patient’s blood volume, which can prevent shock, and helps with blood clotting.

Can FFP be given to any blood group?

The typical administration rate is 10-20mL/kg/hr, but this may vary depending on the patient’s condition. ABO group identical FFP should be given whenever possible; if not possible, FFP of a different ABO group may be acceptable as guided in the blood group selection table. only be given to group O recipients.

Does FFP need to match blood?

Plasma compatibility

Plasma components (e.g. fresh frozen plasma, cryoprecipitate and cryodepleted plasma) should be compatible with the ABO group of the recipient to avoid potential haemolysis caused by donor anti-A or anti-B. Plasma components of any RhD type can be given regardless to the RhD type of the recipient.

Do we need crossmatch for FFP?

FFP transfusions must be ABO compatible, but Rh compatibility and cross-matching are not required (Table 35.1).

Why are platelets given to patients?

Platelet transfusion is a lifesaving procedure that is carried out to prevent bleeding or stop ongoing bleeding in patients with low platelet count or functional platelet disorders.

What is the universal donor for FFP?


The universal FFP donor, conversely, is AB because it will contain neither anti-A nor anti-B antibodies. Whole blood donors and recipients must be exact ABO matches because whole blood contains both RBCs and serum.

Is cross matching necessary for platelets?

Platelet transfusions from RhD-positive donors to recipients with anti-D antibodies do not result in hemolysis, because they contain very few RBCs. Only products containing >2 mL of incompatible RBCs require a serologic crossmatch per AABB standards.

When should you crossmatch blood?

A crossmatch is performed prior to administration of blood or blood products (e.g. packed red blood cells). The purpose of the crossmatch is to detect the presence of antibodies in the recipient against the red blood cells of the donor. These antibodies attach to the red blood cells of the donor after transfusion.

Do platelets need to be Rh compatible?

Although platelets do not express Rh antigens, they contain small numbers of intact red blood cells or fragments, which can lead to alloimmunization in the recipient. Alloimmunization to the RhD antigen may occur when platelets obtained from RhD-positive donors are transfused to RhD-negative recipients.

What are the indications of cross matching?

It serves two purposes: (1) to serve as a final check of ABO compatibility between donor red blood cells (RBCs) and patient plasma or serum and (2) to detect clinically significant antibodies that may have been missed by the antibody screening test.

What precautions must be taken before giving a blood transfusion?

Before your transfusion, your nurse will: Check your blood pressure, pulse and temperature. Make sure the donor blood type is a match for your blood type.

Which medication is being given prior to blood transfusion?

In an attempt to prevent these reactions, US physicians prescribe acetaminophen or diphenhydramine premedication before more than 50% of blood component transfusions.

Why is major cross matching important?

Major crossmatching is a mandatory test that checks to see if the blood recipient has any antibodies that might resist the donor’s blood cells. To do this test, blood cells from the donor are combined with blood serum from the recipient. Without this test, a blood bank cannot release blood donations to a patient.

What are the 3 phases of cross matching?

The three phases of compatibility testing are listed below:

  • Saline Phase: Where the immunologic reaction between red cells suspended in saline medium and the antibody occurs at room temperature.
  • Thermo Phase with Protein: …
  • Antihuman Globulin (AHG) Phase:

Who regulates Bloodbanks?

U.S. Food and Drug Administration (FDA)

The U.S. Food and Drug Administration (FDA) is responsible for overseeing and regulating the U.S. blood supply. FDA enforces standards for blood collection and distribution of blood products.