What would happen if the choroid plexus produces excessive CSF?

This excess CSF in the brain (hydrocephalus) can create pressure in the brain that can be dangerous. Even if a CPP is not cancer, it can still cause problems. It may press against brain tissue and cause symptoms, such as headache, vision problems, or nausea and vomiting.

How does choroid plexus produce CSF?

The choroid plexus folds into many villi around each capillary, creating frond-like processes that project into the ventricles. The villi, along with a brush border of microvilli, greatly increase the surface area of the choroid plexus. CSF is formed as plasma is filtered from the blood through the epithelial cells.

What is the diagnostic significance of choroid plexus cells in CSF?

Clinical Significance
The choroid plexus may be involved in various pathologies that are groupable into two main categories; high volume states of CSF and low volume states of CSF. Low volume states of CSF are most commonly due to CSF leak but may also be due to damage to the ependymal cells of the ventricles.

What is choroid plexus tumor symptoms?

Symptoms. The most common symptoms of choroid plexus tumors are hydrocephalus and signs of increased intracranial pressure, which include headache, nausea, vomiting, and lethargy. A headache typical of excessive intracranial pressure is most severe in the morning upon waking and may abate as the day progresses.

What causes choroid plexus carcinoma?

Genes may be mutated (changed) in many types of cancer, which can increase the growth and spread of cancer cells. The cause of most choroid plexus tumors is not known. Genetic changes have been linked to the formation of some choroid plexus tumors.

What increases CSF production?

The increased CSF production is the result of an increased activity of Na+-K+ ATPase at the choroid plexus level, which establishes a sodium gradient across the choroid epithelial cells, as well as of an elevated CBF (66).

What is the purpose of CSF?

Also called CSF. Cerebrospinal fluid (CSF, shown in blue) is made by tissue that lines the ventricles (hollow spaces) in the brain. It flows in and around the brain and spinal cord to help cushion them from injury and provide nutrients.

What does excess accumulation of CSF in the ventricles cause?

Hydrocephalus is an abnormal buildup of fluid in the ventricles (cavities) deep within the brain. This excess fluid causes the ventricles to widen, putting pressure on the brain’s tissues. Cerebrospinal fluid (CSF) is the clear, colorless fluid that protects and cushions the brain and spine.

How many percent of CSF is formed in the ventricular choroid plexus?


CSF is a clear, watery fluid that fills the ventricles of the brain and the subarachnoid space around the brain and spinal cord. CSF is primarily produced by the choroid plexus of the ventricles (≤70% of the volume); most of it is formed by the choroid plexus of the lateral ventricles.

How is cerebrospinal fluid affected by meningitis?

Close examination of the cerebrospinal fluid: The fluid is normally clear but may be cloudy in people with meningitis. Measurement of the pressure in the subarachnoid space (which contains the cerebrospinal fluid) as the cerebrospinal fluid is withdrawn: Pressure is usually high in meningitis.

Where is CSF produced?

CSF is secreted by the CPs located within the ventricles of the brain, with the two lateral ventricles being the primary producers.

What is the choroid plexus in the brain?

A network of blood vessels and cells in the ventricles (fluid-filled spaces) of the brain. The blood vessels are covered by a thin layer of cells that make cerebrospinal fluid.

Why does retinoblastoma occur in the eye?

Retinoblastoma occurs when nerve cells in the retina develop genetic mutations. These mutations cause the cells to continue growing and multiplying when healthy cells would die. This accumulating mass of cells forms a tumor. Retinoblastoma cells can invade further into the eye and nearby structures.

What happens if CSF pressure is high?

Intracranial hypertension means that the pressure of the fluid that surrounds the brain (cerebrospinal fluid or CSF) is too high. Elevated CSF pressure can cause two problems, severe headache and visual loss. If the elevated CSF pressure remains untreated, permanent visual loss or blindness may result.

What happens if CSF flow is disrupted?

Disruption of normal CSF circulation and turnover is believed to contribute to the development of many diseases, including neurodegenerative conditions such as Alzheimer’s disease, ischemic and traumatic brain injury, and neuroinflammatory conditions such as multiple sclerosis.

What happens if CSF is not drained properly?

CSF is constantly being made and absorbed by your body. CSF moves through ventricles before it drains out and gets absorbed into your bloodstream. When CSF cannot drain properly, the fluid pressure may cause the ventricles to swell.

What does it mean if an unborn baby has fluid on the brain?

Hydrocephalus, or “water on the brain,” is a condition associated with a buildup of cerebrospinal fluid (CSF) in or around the brain. If left untreated, this can lead to brain tissue stretching, significantly affecting your child’s growth and development.

What happens if a baby has fluid on the brain?

Most CSF is found in fluid-filled areas (ventricles) inside the brain. Its purpose is to cushion and protect the brain and the spinal cord. Too much CSF can increase the pressure in your baby’s head. This causes the bones in your baby’s skull to expand and separate.

What happens if you drain too much CSF from a lumbar drain?

There is a potential for bleeding around the brain if excess fluid is drained. This procedure has been performed over 1,000 times and only one patient experienced blood inside the skull. This patient had to have surgery to remove the blood.

What are two biggest risks of lumbar drains?

A lumbar drain can lead to various complications, including intracranial venous thrombosis and infection. (For critical complications, see Life-threatening complications.)

What causes hydrocephalus?

Hydrocephalus is caused by an imbalance between how much cerebrospinal fluid is produced and how much is absorbed into the bloodstream. Cerebrospinal fluid is produced by tissues lining the ventricles of the brain. It flows through the ventricles by way of interconnecting channels.