What organs are damaged mostly by taking NSAIDs?

However, data from multiple placebo-controlled trials and meta-analyses studies alarmingly signify the adverse effects of NSAIDs in gastrointestinal, cardiovascular, hepatic, renal, cerebral and pulmonary complications.

Which organ is most affected by NSAIDs?

Ibuprofen and other NSAIDs block prostaglandins, natural body chemicals that normally dilate blood vessels leading to the kidneys. Blocking prostaglandins may lead to decreased blood flow to the kidneys, which means a lack of oxygen to keep the kidneys alive. That can cause acute kidney injury.

What organs do NSAIDs damage?

The action of NSAIDs on major organs including stomach, small intestine, heart, liver, kidney, respiratory tract and brain is mainly mediated through PGHS-dependent prostanoid modulation and alteration of mitochondrial functional integrity leading to mitochondrial oxidative stress (MOS) generation, depolarization of …

What damage can NSAIDs do?

Like many other drugs, however, NSAIDs are associated with a broad spectrum of side effects, including gastrointestinal (GI) and cardiovascular (CV) events, renal toxicity, increased blood pressure, and deterioration of congestive heart failure among others.

What is the most common serious adverse effects of NSAIDs?

The most frequently reported side effects of NSAIDs are gastrointestinal (stomach and gut) symptoms, such as:

  • Gas.
  • Feeling bloated.
  • Heartburn.
  • Stomach pain.
  • Nausea.
  • Vomiting.
  • Diarrhea and/or constipation.

What are the long term effects of taking NSAIDs?

Older adults commonly take nonsteroidal anti-inflammatory drugs (NSAIDs) chronically. Studies of older adults show that chronic NSAID use increases the risk of peptic ulcer disease, acute renal failure, and stroke/myocardial infarction.

Can kidneys recover from NSAID damage?

Treatment. Renal function will recover in most patients after withdrawal of NSAID therapy. Steroids may aid recovery in patients with interstitial nephritis who do not improve after stopping NSAID therapy.

Which of the following are potential side effects of NSAIDs in older adults?

NSAIDs, like other drugs, have the risk of side effects. Older people and those with some chronic illnesses may have increased risk for side effects from NSAIDs.
These include:

  • irritation or pain.
  • heartburn.
  • gas.
  • diarrhea or constipation.
  • bleeding and ulcers.
  • nausea.
  • vomiting.

How do NSAIDs affect the kidneys?

NSAIDs may increase your fluid retention and can lead to decreased blood flow to kidneys. This is because NSAIDs block prostaglandins, which are the natural chemicals that dilate blood vessels and allow oxygen to reach the kidneys to keep them alive and healthy.

What health problems can anti-inflammatory medications cause?

Common side effects of NSAIDs include:

  • Stomach pain and heartburn.
  • Stomach ulcers.
  • A tendency to bleed more, especially when taking aspirin. …
  • Headaches and dizziness.
  • Ringing in the ears.
  • Allergic reactions such as rashes, wheezing, and throat swelling.
  • Liver or kidney problems. …
  • High blood pressure.

Why do NSAIDs cause side effects?


From the first day of use, all NSAIDs increase the risk of gastrointestinal (GI) bleeding, myocardial infarction, and stroke. NSAIDs reduce prostaglandin synthesis, with differences in the extent of inhibition of the enzymes COX-1 and COX-2.

Is it OK to take NSAIDs everyday?

You should never take any over-the-counter medicine regularly without discussing it with your doctor. Most over-the-counter painkillers should not be used for more than 10 days. Like any medicine, over-the-counter and prescription NSAIDs have side effects.

When are side effects from an NSAID most likely to occur?

Hepatotoxicity secondary to NSAIDs can occur at any time, but is most likely to happen six to 12 weeks after administration. Risk factors for NSAID-induced idiosyncratic hepatotoxicity include female sex, age greater than 50 years, and underlying autoimmune disease.

Is gabapentin an NSAID?

Examples would include gabapentin, tramadol and amitriptyline. NSAIDs can cause stomach and intestinal problems, damage the kidneys and less commonly the liver and bone marrow. These problems are uncommon to rare, especially with appropriate monitoring.

Is there an anti-inflammatory that is not an NSAID?

Several non-NSAID, non-narcotic therapies are available for noninflammatory pain. Acetaminophen is as effective as NSAIDs for the management of mild-to-moderate OA pain and is the recommended first-line therapy by the American College of Rheumatology (ACR).

What happens when you stop taking NSAIDs?

Stopping NSAIDs Suddenly Poses Heart-Related Risks

The body’s reaction to such a cutoff could make blood clots more likely, adding to the risk of heart attack or stroke. Instead, a person who is regularly using NSAIDs should talk with a doctor about the best way to taper off.

What is considered long-term NSAID use?

Recommendations for long-term NSAID use

NSAID use is defined as chronic if these medications are taken more than three times a week for more than three months.

Can NSAIDs cause permanent damage?

In fact, 15-30% of these long-term NSAID users are at risk of developing ulcer disease, with 2-4% of these ulcers leading to complications. Chronic NSAID use can even result in death, with one study estimating 7,000-16,500 individuals in the United States dying from NSAID complications each year.

How long does it take for NSAID to get out of your system?

Official Answer. After taking your last dose of naproxen it should be out of your system within 93.5 hours. Naproxen has an elimination half life of 12 to 17 hours. This is the time it takes for your body to reduce plasma drug levels by half.

Does drinking water help reduce inflammation?

Inflammation. Health experts recommend that a diet rich in anti-oxidants as well as staying hydrated with enough water are great ways to reduce inflammation in the body. Water is specifically recommended because it can flush toxins and other irritants out of the body.

Can NSAIDs cause weight gain?

Taking ibuprofen doesn’t increase body fat and it won’t make you eat more. However, it can affect your kidneys if you already have kidney problems or if you take it frequently for long periods of time. When your kidneys don’t function properly, you can retain water, which may appear to be weight gain.

Are banana anti-inflammatory?

Bananas are not a typical choice for people with arthritis, but the antioxidant and anti-inflammatory properties in them may aid in protecting the body against certain oxidative stress.

Is peanut butter anti-inflammatory?

Are peanuts inflammatory? The short answer is no, and in fact, peanuts and some peanut products like peanut butter have been shown to be anti-inflammatory. Inflammation in the body is a mechanism thought to be at the center of the majority of chronic diseases.

Is coffee anti-inflammatory?

Coffee contains active compounds with antioxidant and anti-inflammatory properties that may help reduce low grade inflammation and protect against certain diseases.