What medication can decrease the effectiveness of phenytoin?

Drugs that may decrease phenytoin levels and reduce effectiveness include carbamazepine, chronic alcohol abuse, reserpine, and sucralfate (Carafate).

What drugs interact with phenytoin?

Drugs Affected By Phenytoin

Interacting Agent Examples
Other Corticosteroids, doxycycline, estrogens, furosemide, oral contraceptives, paroxetine, quinidine, rifampin, sertraline, theophylline, and vitamin D
Drugs whose level is decreased by phenytoin

What drugs decrease phenytoin levels?

Serum levels of phenytoin are decreased by the following:

  • Antineoplastic drugs.
  • Calcium.
  • Diazepam.
  • Diazoxide.
  • Ethanol (long-term use),
  • Folic acid.
  • Phenobarbital.
  • Rifampin.

What is contraindicated with phenytoin?

Hypersensitivity to phenytoin or other hydantoins is a contraindication for using phenytoin. Pregnancy is another absolute contraindication for phenytoin use.

Does phenytoin interact with many drugs?

Phenytoin is well known for causing clinically significant drug-drug interactions.

What drugs should not be taken with Dilantin?

You should not use Dilantin if you also take delavirdine (Rescriptor), or if you are allergic to phenytoin, ethotoin (Peganone), fosphenytoin (Cerebyx), or mephenytoin (Mesantoin). If you are pregnant, DO NOT START TAKING this medicine unless your doctor tells you to.

What drugs increase phenytoin levels?

Drugs which may increase phenytoin serum levels include: acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, cimetidine, diazepam, dicumarol, disulfiram, estrogens, ethosuximide, fluoxetine, H2-antagonists, halothane, isoniazid, methylphenidate, phenothiazines, phenylbutazone, salicylates, succinimides

Which feature of phenytoin makes it most susceptible to drug interactions?

Phenytoin is particularly susceptible to inhibitory drug interactions because it is subject to saturable metabolism. Inhibition of metabolism may produce significant increases in circulating phenytoin concentrations and enhance the risk of drug toxicity.

What might affect the efficacy of Dilantin?

Drugs that may decrease phenytoin levels and reduce effectiveness include carbamazepine, chronic alcohol abuse, reserpine, and sucralfate (Carafate).

Does warfarin affect phenytoin?

Warfarin is thought to inhibit the metabolism of phenytoin though plasma phenytoin levels may not be affected. [1] Alternatively, prothrombin time is thought be prolonged when phenytoin is added to warfarin therapy due to potentiation of warfarin half-life by phenytoin.

Can cimetidine decrease the effectiveness of phenytoin?

The protein binding of phenytoin was not changed by cimetidine.

Can you take ibuprofen with phenytoin?

Phenytoin – Taking an NSAID and phenytoin (Dilantin, Phenytek) can increase the phenytoin level. As a result, people who take phenytoin should have a blood test to monitor the phenytoin level when starting or increasing the dose of an NSAID.

Can Dilantin stop working?

Stopping DILANTIN suddenly can cause serious problems. Stopping a seizure medicine suddenly in a patient who has epilepsy can cause seizures that will not stop (status epilepticus). Do not change your dose of DILANTIN without talking to your healthcare provider. Only your doctor can recommend changing your medication.

Can you take aspirin with phenytoin?

For instance, aspirin (ASA) is generally safe to take with phenytoin at the usual doses, but if more than 1500 mg per day is taken, the level of phenytoin in the blood will be increased.

Does aspirin displace phenytoin?

The important point is that the addition of aspirin will lead to a decrease in the total phenytoin level (20, 21), which might tempt the clinician to inappropriately increase the phenytoin dose in order to bring the total level back to its original value.

Can I take naproxen with phenytoin?

Interactions between your drugs
No interactions were found between Aleve and Dilantin.

What causes phenytoin toxicity?

Phenytoin toxicity can occur from an increase in the daily dose of phenytoin, changes in the formulations or brands as well as changes in the frequency of administration. It can also occur when patients are started on new medications that interact with the metabolism or binding capacity of phenytoin to plasma proteins.

Which conditions may occur as a result of an overdose of phenytoin DILANTIN?

An overdose of phenytoin can be fatal.
Overdose symptoms may include twitching eye movements, slurred speech, loss of balance, tremor, muscle stiffness or weakness, nausea, vomiting, feeling light-headed, fainting, and slow or shallow breathing.

What is unique about the elimination of phenytoin?

Phenytoin has unique pharmacokinetics. At therapeutic levels, elimination follows first-order kinetics. In the upper therapeutic and toxic range, elimination changes from first-order to zero-order kinetics due to saturation of the hepatic hydroxylation system.