What is the meaning of Hypogammaglobulinemia?

Listen to pronunciation. (HY-poh-GA-muh-GLAH-byoo-lih-NEE-mee-uh) A condition in which the level of immunoglobulins (antibodies) in the blood is low and the risk of infection is high.

What is the cause of hypogammaglobulinemia?

The most common cause is common variable immunodeficiency (CVID). Causes of secondary hypogammaglobulinemia include gastrointestinal losses (e.g., malabsorption/protein-losing enteropathy), nephrotic syndrome, hematologic malignancy, and medication (e.g., immunosuppressives, such as corticosteroids and chemotherapy).

Is hypogammaglobulinemia serious?

People with hypogammaglobulinemia can more easily catch pneumonia, meningitis, and other infections that a healthy immune system would normally protect against. These infections can damage organs and lead to potentially serious complications.

What does it mean to have hypogammaglobulinemia?

Hypogammaglobulinemia is a disorder caused by low serum immunoglobulin or antibody levels. Immunoglobulins are the main components of the humoral immune response and able to recognize antigens to trigger a biological response and eradicate the infectious source.

What is the treatment for hypogammaglobulinemia?

The standard treatment for hypogammaglobulinemia is IgG replacement, which may be given intravenously or subcutaneously.

What medications can cause hypogammaglobulinemia?

Hypogammaglobulinemia may result from other anticonvulsants and anti-inflammatory medications, including valproic acid, phenytoin, gold, sulfasalazine, chloroquine, penicillamine, fenclofenac, hydantoin, zonisamide, lamotrigine, and cyclosporine A (1, 4, 5, 9).

What is the test for hypogammaglobulinemia?

Levels of serum immunoglobulin

In these patients, nucleic acid detection methods (ie, PCR or reverse PCR) may be the best diagnostic tests for certain viral infections. Perform serum protein electrophoresis for presumptive diagnosis of hypogammaglobulinemia or monoclonal protein.

Is Hypergammaglobulinemia serious?

Dangers to people with hypergammaglobulinemia

High levels of gamma globulins in the blood are dangerous because these can lead to an increased likelihood of contracting viruses and infections. Hypergammaglobulinemia leads to increased vulnerability to: anemia. respiratory infections.

How serious is IgG deficiency?

People with IgG deficiency are more likely to get infections. When your body feels it is under attack, it makes special proteins called immunoglobulins or antibodies. These antibodies are made by the plasma cells. They are let loose throughout the body to help kill bacteria, viruses, and other germs.

Can you grow out of hypogammaglobulinemia?

Most children born with transient hypogammaglobulinemia of infancy will grow out of it between the ages of 2 and 5. Other types of hypogammaglobulinemia are lifelong conditions. The risk of infection can be reduced by different treatments, depending on the type and cause of hypogammaglobulinemia.

Is hypogammaglobulinemia considered a disability?

Hypogammaglobulinemia does not have a specific heading under the Social Security Administration’s Listing of Impairments.

What kind of doctor treats IgG deficiency?

You’ll likely start by seeing your family doctor or primary doctor. You might then be referred to a doctor who specializes in disorders of the immune system (immunologist).