What is the drug pentoxifylline used for?

Pentoxifylline improves the flow of blood through blood vessels. It is used to reduce leg pain caused by poor blood circulation. Pentoxifylline makes it possible to walk farther before having to rest because of leg cramps. Pentoxifylline is available only with your doctor’s prescription.

What are the side effects of pentoxifylline?

Common Side effects of Pentoxifylline include:

  • nausea.
  • vomiting.
  • gas.
  • bloating.
  • belching.
  • upset stomach.
  • diarrhea.
  • dizziness.

Is pentoxifylline considered a blood thinner?

The blood thinning properties of pentoxifylline have been attributed to its ability to increase the deformability of red blood cells and improve their rheological properties.

Is pentoxifylline a steroid?

Pentoxifylline, also known as oxpentifylline, is a xanthine derivative used as a drug to treat muscle pain in people with peripheral artery disease. It is generic and sold under many brand names worldwide.

Clinical data
CAS Number 6493-05-6
PubChem CID 4740
DrugBank DB00806

Why is pentoxifylline given?

Pentoxifylline (PTXF) is a vasoactive agent that improves the flow of blood by reducing its viscosity. It is FDA approved for the symptomatic treatment of claudication. Pentoxifylline is also used off-label for the treatment of venous ulcers and severe alcoholic hepatitis.

Does pentoxifylline help with pain?

Pentoxifylline can decrease the muscle aching/pain/cramps during exercise, including walking, that occur with intermittent claudication. Pentoxifylline belongs to a class of drugs known as hemorrheologic agents. It works by helping blood flow more easily through narrowed arteries.

Is pentoxifylline an anti-inflammatory?

Pentoxifylline, a drug with anti-inflammatory, immunomodulatory, and bronchodilatory effects, has previously been shown to inhibit several viral infections. Immunological studies have shown that most patients with severe COVID-19 exhibit substantially elevated serum levels of pro-inflammatory cytokines.

How safe is pentoxifylline?

Overall, pentoxifylline is a very safe drug and is usually well tolerated. The side-effects are dose-related and the most common are those of the gastrointestinal tract and central nervous system. The main central nervous system side effects are dizziness, headache, anxiety and confusion.

Does pentoxifylline make you tired?

Central nervous system: Drowsiness/sleepiness, tremor, agitation anxiety, confusion, insomnia, restlessness. Gastrointestinal: Abdominal burning, abdominal pain, anorexia flatus, constipation, haemorrhage, heartburn, salivation, dry mouth/throat, hepatitis, jaundice, increased liver enzymes.

Can you take pentoxifylline long term?

Conclusions: A substantial number of patients who have been on long-term successful pentoxifylline therapy for claudication can be weaned from the drug. Asymptomatic deterioration of treadmill test parameters is not an indication for resuming therapy.

Does pentoxifylline cause weight loss?

Pentoxifylline decreased the anorexia, the loss of body weight and muscle protein observed in INF-C animals, and partially prevented the decrease in muscle protein synthesis induced by infection.

Can pentoxifylline cause high blood pressure?

Pentoxifylline did not alter blood pressure or plasma IL-6 concentration but did significantly decrease circulating TNF-α and C-reactive protein (CRP) concentrations, a study in the Journal of Hypertension reported.

Can I take Tylenol with pentoxifylline?

Interactions between your drugs
No interactions were found between pentoxifylline and Tylenol. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Can pentoxifylline cause insomnia?

Nervous system side effects have occurred in 1% to 2% of treated patients and have included headache, dizziness, insomnia, and tremor. Some smaller studies have reported nervous system adverse effects in up to 17% of treated patients. In addition, rare cases of visual and auditory hallucinations have been reported.

Can you drink alcohol on pentoxifylline?

You may feel dizzy or faint when you get up quickly after sitting or lying down. Getting up slowly may help. Also, drinking alcohol may make it worse. Do not drink alcohol unless your healthcare provider approves.

What can I take for inflammation while on blood thinners?

If you take blood thinners, such as Coumadin, Plavix, or Eliquis, your doctor may recommend taking Tylenol for pain as opposed to aspirin or ibuprofen. Some people do take both aspirin and another blood thinner, but only under their doctors’ recommendations.

What can I take for joint pain while on blood thinners?

Acetaminophen is the safest pain reliever while taking an anticoagulant – but do not exceed the recommended daily dose!

What can you not do while on blood thinners?

Because you are taking a blood thinner, you should try not to hurt yourself and cause bleeding. You need to be careful when you use knives, scissors, razors, or any sharp object that can make you bleed. You also need to avoid activities and sports that could cause injury. Swimming and walking are safe activities.