What is the difference between SJS and TEN?

SJS is the less severe end, but still represents a serious condition and potential medical emergency. TEN is a severe, life-threatening disorder.

What is the difference between Stevens-Johnson syndrome and toxic epidermal necrolysis?

Stevens-Johnson syndrome causes only small areas of peeling skin (affecting less than 10% of the body). Toxic epidermal necrolysis causes large areas of peeling skin (affecting over 30% of the body).

How do you get SJS TEN?

Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) Stevens-Johnson syndrome and toxic epidermal necrolysis are severe cutaneous hypersensitivity reactions. Drugs, especially sulfa drugs, antiseizure drugs, and antibiotics, are the most common causes.

What is a TEN rash?

Toxic epidermolysis necrosis on a woman’s back
TEN causes large areas of blistering, peeling skin. Toxic epidermal necrolysis (TEN) is a rare, life-threatening skin reaction, usually caused by a medication. It’s a severe form of Stevens-Johnson syndrome (SJS).

What is the treatment for toxic epidermal necrolysis?

Almost everyone with TEN is given antibiotics to prevent or treat any infections. Intravenous immunoglobulin G (IVIG). Immunoglobulins are antibodies that help your immune system. IVIG is sometimes used to control the reaction.

What drugs cause toxic epidermal necrolysis?

Drugs often associated with the onset of toxic epidermal necrolysis include:

  • Antiepileptic drugs.
  • Corticosteroids.
  • Antiretroviral drugs abacavir and nevirapine.
  • Antibiotics.
  • Allopurinol.
  • NSAIDs (non-steroidal anti-inflammatory drugs)‌

What does TEN look like?

TEN then causes a painful skin rash before progressing to large areas of blistering and peeling skin. Erosions, or painful open wounds that look like burns, develop as the skin peels away. Erosions tend to start on the face and chest.

Does Stevens-Johnson syndrome go away on its own?

The syndrome often begins with flu-like symptoms, followed by a red or purple rash that spreads and forms blisters. The affected skin eventually dies and peels off. Stevens-Johnson syndrome is a medical emergency that requires treatment in hospital, often in intensive care or a burns unit.

Which drug has a high risk of Stevens-Johnson syndrome?

Medications most likely to cause Stevens-Johnson syndrome include: Antibacterial sulfa drugs. Anti-epileptic drugs, including phenytoin (Dilantin®), carbamazepine (Tegretol®), lamotrigine (Lamictal®), and phenobarbital (Luminal®). Allopurinol (Aloprim®, Zyloprim®), a drug used to treat gout and kidney stones.

Can you recover from Stevens-Johnson syndrome?

Stevens-Johnson syndrome is a medical emergency that usually requires hospitalization. Treatment focuses on removing the cause, caring for wounds, controlling pain and minimizing complications as skin regrows. It can take weeks to months to recover.

Which antibiotics cause Steven Johnson syndrome?

Antibiotics are the most common cause of Stevens-Johnson syndrome, followed by analgesics, cough and cold medication, NSAIDs, psycho-epileptics, and antigout drugs. Of antibiotics, penicillins and sulfa drugs are prominent culprits; ciprofloxacin has also been reported.

Where does Steven Johnson rash start?

Within about 1 to 3 days, a red or purplish rash forms, and then the skin begins to blister and peel, leading to “raw” areas of skin that are painful. This often starts on the face and then spreads to other parts of the body.

How is Steven Johnson syndrome diagnosed?


  1. A review of your medical history and a physical exam. Health care providers often can identify Stevens-Johnson syndrome based on your medical history, including a review of your current and recently stopped medications, and a physical exam.
  2. Skin biopsy. …
  3. Culture. …
  4. Imaging. …
  5. Blood tests.

What mimics Steven Johnson Syndrome?

Acute Generalized Exanthematous Pustulosis (AGEP) is an uncommon yet severe skin reaction that is often confused with SJS/TEN. It is a drug reaction presenting with non-follicular, sterile pustules on an erythematous and edematous base.

What is epidermal necrolysis?

What is toxic epidermal necrolysis? Toxic epidermal necrolysis is a life-threatening skin disorder characterized by a blistering and peeling of the skin. This disorder can be caused by a drug reaction—often antibiotics or anticonvulsives.

What is the difference between erythema multiforme and Stevens-Johnson?

Results Erythema multiforme majus significantly differed from Stevens-Johnson syndrome, overlap, and toxic epidermal necrolysis by occurrence in younger males, frequent recurrences, less fever, milder mucosal lesions, and lack of association with collagen vascular diseases, human immunodeficiency virus infection, or

What can be mistaken for erythema multiforme?

Urticaria multiforme is commonly misdiagnosed as either erythema multiforme, a serum-sickness-like reaction, or urticarial vasculitis.

What are 3 causes of erythema?

Other rare causes include vaccines and cancers. Vaccines associated with erythema multiforme include the MMR (measles, mumps, and rubella) vaccine, and those for smallpox, hepatitis B, varicella, and influenza.