What is ITP and TTP?

Both immune thrombocytopenia (ITP) and thrombotic thrombocytopenic purpura (TTP) are disorders that affect platelets. They may exhibit similar symptoms, however there are differences in the causes, complications, and treatments of the disorders.

What is TTP?

Thrombotic thrombocytopenic purpura (TTP) is a blood disorder in which platelet clumps form in small blood vessels. This leads to a low platelet count (thrombocytopenia).

What is TTP caused by?

What causes TTP? TTP occurs when you do not have the right amount of an enzyme (a type of protein in your blood) called ADAMTS13. This enzyme controls how your blood clots. If you do not have enough ADAMTS13, your body makes too many blood clots.

How does a person get ITP?

Immune thrombocytopenia usually happens when your immune system mistakenly attacks and destroys platelets, which are cell fragments that help blood clot. In adults, this may be triggered by infection with HIV , hepatitis or H. pylori — the type of bacteria that causes stomach ulcers.

What is TTP treatment?

For acquired TTP, medicines can slow or stop antibodies to the ADAMTS13 enzyme from forming. Medicines used to treat TTP include glucocorticoids, vincristine, rituximab, and cyclosporine A. Sometimes surgery to remove the spleen (an organ in the abdomen) is needed.

Is TTP the same as ITP?

Are ITP and TTP the same thing? No, ITP and TTP are not the same thing. Both ITP and TTP are bleeding disorders, but they occur for different reasons and may require different treatments.

Is TTP an autoimmune disease?

This form or TTP is considered to be an autoimmune disease and is caused when patients develop an antibody against the ADAMTS13 protease leading to low levels of the protease. If the disorder is present at birth (familial form), signs and symptoms may typically appear earlier, in infancy or early childhood.

Can TTP be cured?

Can TTP Be Cured? About 80% of patients will survive. The majority of patients will have only one episode of TTP; few will have relapses.

How is TTP diagnosed?

Which tests can confirm a diagnosis of thrombotic thrombocytopenic purpura (TTP)?

  1. Complete blood count (CBC). …
  2. Bilirubin test. …
  3. Blood smear. …
  4. Urine or kidney function tests. …
  5. Creatinine test. …
  6. Lactate dehydrogenase test. …
  7. ADAMTS13 assay.

How long can you live with TTP?

The most striking evidence for the impact of morbidities following recovery from TTP is decreased survival. Among the 77 patients who survived their initial episode of TTP (1995-2017), 16 (21%) have subsequently died, all before their expected age of death (median difference, 22 years; range 4-55 years).

Can TTP come back?

Our experience is that TTP can recur during pregnancy, but this is uncommon. Most women have uncomplicated, successful pregnancies.

What drugs can cause TTP?

Drugs such as mitomycin, cyclosporine, cisplatin, bleomycin, quinine, and ticlopidine have been associated with HUS and TTP.

Is TTP a disability?

If you are disabled because of Chronic Thrombocytopenia that is so severe it prevents you from working, you may well be entitled to Social Security Disability benefits.

Is TTP painful?

Our data confirm that patients with TTP present with a wide range of symptoms, not immediately suspicious for TTP, such as abdominal pain, nausea and vomiting.

Does ITP shorten life expectancy?

Predicted 5-year mortality rates ranged from 2.2% for patients younger than 40 years to 47.8% for those older than 60 years. A 30-year-old woman remaining thrombocytopenic due to ITP was predicted to lose 20.4 years (14.9 quality-adjusted life years) of her potential life expectancy.

How long do you live with ITP?

For most people with ITP, the condition isn’t serious or life-threatening. For example, acute ITP in children often resolves within 6 months or less without treatment. Chronic ITP, though, can last for many years. Still, people can live for many decades with the disease, even those with severe cases.

Is ITP a form of leukemia?

Immune thrombocytopenia (ITP) is not cancer, although some confuse it with blood cancer (leukemia). If you have a low platelet count (thrombocytopenia), your doctor will first rule out conditions, such as ITP, before thinking of blood cancer. Cancer treatments can also result in ITP.

What happens if ITP is not treated?

The specific symptoms of ITP are affected by your platelet count: The lower your count, the more likely you are to have spontaneous and unexpected bleeding, both internally and externally. Without treatment to correct platelet counts, bleeding can become severe and life threatening.

What foods should you avoid with ITP?

The Association recommends plenty of fruits and vegetables, whole grain bread and other starches, lower-fat dairy, lean meat, fish, eggs, beans, nuts, and seeds. They also recommend avoiding foods high in fat and sugar.

Do low platelets make you tired?

Things to know about thrombocytopenia (low platelet count) Symptoms and signs of thrombocytopenia may include fatigue, bleeding, and others.

Can vitamin D increase platelets?

Increased platelet counts were found in people with low vitamin D levels. However, there was no significant correlation between vitamin D and age, gender, uric acid, MPV, and ALP in vitamin D groups.

Does aspirin lower platelet count?

Aspirin had no influence in vitro on either platelet count, volume or mass.

Why is aspirin no longer recommended?

The task force concluded that starting a daily aspirin in healthy adults age 60 and older has “no net benefit” and increases a person’s risk of bleeding in the brain or gut. While the risk of bleeding is low, it increases with age.

What drugs cause low platelets?

Platelets are cells in the blood that help the blood clot. A low platelet count makes bleeding more likely.
Other medicines that cause drug-induced thrombocytopenia include:

  • Furosemide.
  • Gold, used to treat arthritis.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Penicillin.
  • Quinidine.
  • Quinine.
  • Ranitidine.
  • Sulfonamides.