What is febrile phase in dengue?

– Febrile phase: high fever (39 to 40 °C) lasting 2 to 7 days, often accompanied by generalized aches, a maculopapular rash and mild haemorrhagic manifestations.

What is febrile stage?

Febrile phase. Patients typically develop high-grade fever suddenly. This acute febrile phase usually lasts 2–7 days and is often accompanied by facial flushing, skin erythema, generalized body ache, myalgia, arthralgia and headache (1). Some patients may have sore throat, injected pharynx and conjunctival injection.

What are the phases of dengue?

Dengue begins abruptly after a typical incubation period of 5–7 days, and the course follows 3 phases: febrile, critical, and convalescent.

What is recovery phase in dengue?

The phase of dengue beyond 6th day of illness is called recovery phase (though a sizable number of patients take longer to recover). When the dengue virus infects a previously non-infected person, it is inferred as primary dengue infection [PDI].

Is dengue a febrile disease?

Dengue, an acute febrile illness, is caused by infection with any of 4 related positive-sense, single-stranded RNA viruses of the genus Flavivirus, dengue viruses 1, 2, 3, or 4.

What is the convalescent stage?

Convalescence is the period in which the body recovers from a serious illness, injury or surgery. Changes to your lifestyle may be needed to make sure the body has enough time and rest to allow a complete recovery.

Why is ultrasound done in dengue?

Ultrasonography is a potentially timely, cost-effective, and easily used modality in the evaluation of potential dengue hemorrhagic fever. Positive and reliable ultrasonographic findings include fluid in the chest and abdominal cavities, pericardial effusion, and a thickened gallbladder wall.

How much platelet count is normal in dengue?

Dengue fever can result in a drop in your white blood cell and platelet counts. The normal platelet count in the body ranges from 1.5 to 4 lacs, this can go down to as low as 20,000 to 40,000 in the case of dengue patients.

What is the critical platelet count in dengue?

A typical person has a platelet count of between 150,000 and 250,000 per microlitre of blood. About 80 to 90 per cent of patients with dengue will have levels below 100,000, while 10 to 20 per cent of patients will see critically low levels of 20,000 or less.

What is convalescent rash?

The rash is typically macular or maculopapular and may be associated with pruritus. (B) Convalescent rash is characterized by confluent erythematous eruption with sparing areas of normal skin. It is often pruritic. The rash typically occurs within one to two days of defervescence and lasts one to five days.

What is plasma leakage in dengue?

Plasma leakage is a process in which the protein rich, fluid component of the blood leaks from blood vessels into the surrounding tissue. Plasma leakage is the most serious complication that distinguishes dengue from severe dengue. For some dengue patients, as fever begins to disappear, severe dengue will develop.

Which test is done for dengue?

Molecular testing (polymerase chain reaction, PCR)—this type of test detects the genetic material of the dengue virus in blood within the first week after symptoms appear (fever) and can be used to determine which of the 4 serotypes is causing the infection.

How can a CBC detect dengue?

Here are the common tests recommended to diagnose dengue:

  1. Dengue NS1 Antigen. This is a blood test to detect the dengue virus early in the course of an infection. …
  2. Immunoglobulin M (IgM) …
  3. Immunoglobulin G (IgG) …
  4. Dengue RNA PCR test.

What does NS1 antigen positive mean?

A positive NS1 test result confirms dengue virus infection without providing serotype information. A negative NS1 test result does not rule out infection. People with negative NS1 results should be tested for the presence of dengue IgM antibodies to determine possible recent dengue exposure.

What is Elisa test for dengue?

What is the test? The dengue MAC-ELISA is used for the qualitative detection of dengue virus IgM antibodies. The MAC-ELISA is based on capturing human IgM antibodies on a microtiter plate using anti-human-IgM antibody followed by the addition of dengue virus antigens.

When should NS1 test be done?

Avinash Phadke Labs, “The NS1 test should be taken on the very first day of the fever striking. It holds relevance after 24 hours also, but ideally should be taken within 24 hours.”

How is NS1 test done?

It is detected in the lab by a method called ELISA (enzyme-linked immunosorbent assay). This protein causes our body to produce an immune response by making antibodies to fight this viral infection. The NS1 antigen is present in the blood of an infected person as soon as the dengue symptoms show up.

What is IgG positive?

IgG antibodies remain in the blood after an infection has passed. These antibodies indicate that you may have had COVID-19 in the recent past and have developed antibodies that may protect you from future infection.

What is a good antibody level?

“You’re more protected at 2,500 than at 1,000. It’s up to you and your risk of exposure, your risk of severe disease, all of those things together, to know whether you need to be at greater than 1,000 or if 1,000 is fine for you.”

What is IgM antibody test?

The first antibody produced by the immune system during a viral infection is IgM. A positive IgM antibody test indicates that the virus may be present and that your body has started the immune response. When IgM is detected you may currently be infected, or you may have recently recovered from a COVID-19 infection.

What is the purpose of IgM?

IgM not only serves as the first line of host defense against infections but also plays an important role in immune regulation and immunological tolerance. For many years, IgM is thought to function by binding to antigen and activating complement system.

Why IgM is produced first?

IgM is the first antibody to be produced in response to infection since it does not require ‘class switch’ to another antibody class. However, it is only synthesized as long as antigen remains present because there are no memory cells for IgM.

How long before IgM is positive?

IgM and IgG antibodies

Typically the IgM antibody develops soon after infection (3 to 10 days), but does not last long. The IgG is often detectable later, after day 9, and can last much longer, months to years.

Why is IgG better than IgM?

IgM is specialized to activate complement efficiently upon binding antigen. IgG antibodies are usually of higher affinity and are found in blood and in extracellular fluid, where they can neutralize toxins, viruses, and bacteria, opsonize them for phagocytosis, and activate the complement system.

What are the 5 antibodies?

There are 5 types of heavy chain constant regions in antibodies (immunoglobulin) and according to these types, they are classified into IgG, IgM, IgA, IgD, and IgE. They are distributed and function differently in the body.

What is the full form of IgG?

Immunoglobulin G (IgG): This is the most common antibody. It’s in blood and other body fluids, and protects against bacterial and viral infections. IgG can take time to form after an infection or immunization.