What is ACell made from?

ACell (ACell, Inc.) is one of the newest xenograft biological dermal substitutes composed of extracellular matrix (ECM) derived from porcine urothelium that is lyophilized and dehydrated.

Is ACell synthetic?

ACell’s non-synthetic, fully-resorbable devices are minimally processed to remove cellular content and mitigate the inflammatory response1,8.

What is ACell wound matrix made of?

ACell’s wound management products are medical devices that maintain and support a healing environment by facilitating remodeling of site-appropriate, functional tissue1. Comprised of naturally-occurring urinary bladder matrix (UBM), these products maintain an intact epithelial basement membrane.

What is ACell MicroMatrix made of?

Comprised of naturally-occurring urinary bladder matrix (UBM). MicroMatrix is appropriate for acute wounds and chronic wounds.

Who makes ACell?

In January 2021, Integra LifeSciences, a regenerative medicine and surgical instrument company, acquired the ACell for $400 million.

What is ACell MatriStem?

ACell’s platform MatriStem UBM™ technology facilitates the body’s ability to remodel functional tissue1. Our mission is to leverage that technology to help patients around the world.

What is urinary bladder matrix?

Urinary bladder matrix (UBM) is an acellular, noncross-linked, resorbable, biologically-derived extracellular matrix (ECM) scaffold that can aid in establishing a neovascularized wound bed in certain wounds.

What is an Integra skin graft?

Integra is a product that is used to help re-grow skin on body parts where skin has been removed or badly damaged. It was initially used to safely cover large areas of burned tissue where skin needed to be regrown. However, Integra is now used far more widely as part of skin grafts in reconstructive surgery.

What is Micro Matrix?

MicroMatrix is a medical device manufactured using proprietary MatriStem UBM™ (Urinary Bladder Matrix) technology. The device maintains an intact epithelial basement membrane and facilitates the body’s ability to remodel site-appropriate tissue.

What is a cell for wound healing?

Fibroblasts are the major cell type responsible for wound ECM remodelling, replacing the initial fibrin clot with hyaluronan, fibronectin and proteoglycans, and forming mature collagen fibrils later in repair [85].

Is ACell FDA approved?

ACell Wins FDA Approval for Concurrent Use of its Wound Management Devices.

Is ACell available in Canada?

Despite it’s FDA approval in the United States, ACell/Matristem is not available in Canada and I’m unable to offer it to Canadian patients. I’ve had numerous discussions with Health Canada and physicians in Canada are not allowed to use the product.

What is ACell mesh?

ACell’s Gentrix® Surgical Matrix devices are an extracellular matrix scaffold which has been shown to facilitate the body’s ability to remodel site- appropriate, biomechanically functional tissue where scarring would be expected1-3. Our product has demonstrated positive patient outcomes with minimal complications4.

Is ACell publicly traded?

This is the initial public offering of shares of common stock of ACell, Inc. We are offering shares of common stock. Prior to this offering, there has been no public market for our common stock.

What is SurgiMend mesh?

SurgiMend® is a unique acellular collagen matrix derived from fetal and neonatal bovine dermis. SurgiMend offers clear advantages over synthetic and other biologic products for soft tissue repair and reconstruction. SurgiMend is the Strongest, Thickest Biologic Matrix 9.

What is Phasix mesh?

Phasix™ Mesh is a knitted monofilament mesh scaffold made of Poly-4-hydroxybutyrate (P4HB), a biologically derived, fully resorbable material.

What is strattice biologic mesh?

STRATTICE™ RTM is: used in the repair of hernias and/or body wall defects that require the use of reinforcing or bridging material to obtain the desired surgical outcome. intended for single-patient one-time use only.

What is Alloderm graft?

Alloderm is an alternative material used for soft tissue grafting that does not require harvesting of tissue from the patient. Alloderm is an accelular dermal matrix material that provides a scaffold on which the body can incorporate new blood vessels and grow new soft tissue cells.

What is AlloDerm made of?

WHAT IS ALLODERM MADE OF? Alloderm, made by LifeCell, is a dehydrated sheet of sterile tissue that is donated from human cadaver skin. It is very pliable and versatile for many plastic surgical procedures.

Where is AlloDerm made?

To stabilize the tissue expander, it is placed under AlloDerm tissue, which is sewn from the pectoralis major muscle to the chest wall. Breast skin then grows into the AlloDerm tissue, which forms an extra protective layer between the implant, when it is inserted, and the surface of the breast.

How are tissue expanders attached?

Placing your tissue expander

There are 2 ways to place your tissue expander: Submuscular placement is when your surgeon places the expander under your large pectoralis muscle in your chest. They will make a pocket under the muscle and place your tissue expander in that space.

Do I need to wear a bra with tissue expanders?

After 14 days you may remove the Surgical Bra and wear a “sports” type bra that will provide support and maintain the placement of the tissue expander. Please do not wear an underwire bra. Please wear a “sports” bra for 24 hours a day for 21 days. You may remove the bra to shower.

How long can tissue expanders be left in?

But keeping the fluid filled expander means that you don’t need to have a second operation. If you are having the expander left in, your surgeon inflates it until it is slightly larger than your natural size. They leave it for 2 to 3 months.

How can you tell if a tissue expander is infected?

Sometimes a bacterial infection can develop in the tissue around a breast implant or tissue expander during the days or weeks following the reconstruction surgery. Symptoms of an infection can include a high fever and breast pain, redness and/or swelling.

Can you pop a breast expander?

A rupture can be caused by a traumatic injury to the chest, through overfilling of the expander, or through a defect in the expander itself. The expander will need to be surgically removed. Depending upon the time in which it ruptures, a new expander may need to be placed, or possibly replaced with the final implant.

How often do tissue expanders get filled?

You will need to make appointments every 1 to 2 weeks for several months to have your expanders inflated. Each expander has a tiny valve that is located under your skin. The surgeon or nurse will inject saline into the valve, filling the expander in stages.