What are the contraindications for nitroglycerin?

The contraindications of nitroglycerine therapy include:

  • Allergic reactions to nitroglycerin are extremely rare, but reports do exist. …
  • Known history of increased intracranial pressure, severe anemia, right-sided myocardial infarction, or hypersensitivity to nitroglycerin are contraindications to nitroglycerin therapy.

What are the 5 contraindications of nitroglycerin?

Who should not take NITROGLYCERIN?

  • significant anemia.
  • methemoglobinemia, a type of blood disorder.
  • severe heart failure.
  • a hemorrhage in the brain.
  • low blood pressure.
  • high pressure within the skull.

What is contraindication to nitrate administration?

Administration of nitrates is contraindicated with concomitant use of phosphodiesterase-5 inhibitors used for the treatment of erectile dysfunction, as combination therapy may lead to profound hypotension and even death.

What is a contraindication to nitroglycerin administration ACLS?

Nitroglycerin Precautions & Contraindications:

Low systolic blood pressure of less than 90 mm/Hg. Right-sided ventricular infarction. Use of tadalafil (sometimes better known as brand names Cialis or Adcirca) within the past 48 hours. Severe bradycardia of less than 50 bpm.

Is nitroglycerin contraindicated in hypertension?

To minimize the risks of nitrates following acute MI, nitroglycerin should not be administered to patients with systolic blood pressure less than 90 mmHg or a change of 30 mmHg or more below baseline, severe bradycardia (less than 50 beats per minute), tachycardia, or suspected right ventricular infarction.

What are the contraindications for epinephrine?

There are no absolute contraindications against using epinephrine. Some relative contraindications include hypersensitivity to sympathomimetic drugs, closed-angle glaucoma, anesthesia with halothane. Another unique contraindication to be aware of is catecholaminergic polymorphic ventricular tachycardia.

What are the side effects of nitroglycerin?


  • Bloating or swelling of the face, arms, hands, lower legs, or feet.
  • burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings.
  • difficult or labored breathing.
  • feeling faint, dizzy, or lightheadedness.
  • feeling of warmth or heat.

Are nitrates contraindicated in heart failure?

Like all vasodilators, nitrates are contraindicated in the setting of hypotension, as well as in LV outflow tract obstruction, and in AHF mimics (e.g., chronic obstructive pulmonary disease) where vasodilation is unlikely to provide a benefit.

Which conditions are indications for nitroglycerin?

Nitroglycerin sublingual tablets are used to treat episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). It is also used just before activities that may cause episodes of angina in order to prevent the angina from occurring.

Why is nitroglycerin contraindicated in stroke?

Abstract. It is reported that nitroglycerin (NTG) induces the elevation of intracranial pressure (ICP). Because of it, the use of NTG in patients exhibiting the increased ICP especially in the neurosurgical field is thought to be avoided.

Is nitroglycerin contraindicated in atrial fibrillation?

Administering nitro in the presence of atrial fibrillation increases the risks for an adverse reaction such as hemodynamic instability where you would notice a fall in cardiac output (ex: fall in blood pressure, pulmonary congestion).

What are contraindications for aspirin?

Aspirin is contraindicated in patients with salicylate hypersensitivity or NSAID hypersensitivity. Aspirin is also contraindicated in patients with the syndrome of asthma, rhinitis, and nasal polyps; aspirin may cause severe urticaria, angioedema, or bronchospasm in these patients.

What is the most serious side effect of nitroglycerin?

Many people using this medication do not have serious side effects. Tell your doctor right away if any of these unlikely but serious side effects occur: fainting, fast/irregular/pounding heartbeat. A very serious allergic reaction to this drug is rare.

Does Nitro lower blood pressure?

Nitroglycerin dilates veins, relieving chest pain and lowering blood pressure.

How much does nitroglycerin lower BP?

At 5 and 10 min after sublingual nitroglycerin, mean reduction of mean arterial blood pressure by 12.3 and 16.3% was achieved.

What precautions are taken when administering nitroglycerin?

Nitroglycerin sublingual tablets should not be chewed, crushed, or swallowed. They work much faster when absorbed through the lining of the mouth. Place the tablet under the tongue or between the cheek and gum, and let it dissolve. Do not eat, drink, smoke, or use chewing tobacco while a tablet is dissolving.

Can you take nitro and aspirin together?

The guideline recommends that the patient with acute coronary syndrome should receive aspirin and a maximum of three doses of nitroglycerin, five minutes apart. However, the current guidelines do not recognize the importance of the order in which these medications should be given [4, 5].

Why is nitroglycerin contraindicated in right sided mi?

Nitroglycerin is also contraindicated in the setting of an inferior MI with right ventricular involvement because, in this specific situation, the heart is dependent on preload.

What type of STEMI do you not give Nitro?

2013 AHA/ACC STEMI Guidelines:

“Nitrates should not be given to patients with hypotension, marked bradycardia or tachycardia, RV infarction, or 5’phosphodiesterase inhibitor use within the previous 24 to 48 hours.”

Can you give Nitro in right heart failure?

In addition, prolonged exposure to nitroglycerin may inhibit aldehyde dehydrogenase (ALDH2), an enzyme that may have a significant cardioprotective role during cardiac events. Administration of nitroglycerin to a patient with right sided heart failure will kill the patient.