What are gastric chief cells?

The gastric chief cell (also known as a zymogenic cell or peptic cell) is a cell in the stomach that releases pepsinogen and chymosin. Pepsinogen is activated into the digestive enzyme pepsin when it comes in contact with hydrochloric acid produced by gastric parietal cells.

What is gastric chief?

A gastric chief cell (or peptic cell, or gastric zymogenic cell) is a type of gastric gland cell that releases pepsinogen and gastric lipase and is the cell responsible for secretion of chymosin in ruminants.

What is meant by chief cell?

Medical Definition of chief cell

1 : one of the cells that line the lumen of the fundic glands of the stomach: a : a small cell with granular cytoplasm that secretes pepsin. b : a larger cell with hyaline cytoplasm and a mucoid secretion — compare parietal cell.

What do chief cells of gastric mucosa?

(2) Zymogenic, or chief, cells are located predominantly in gastric glands in the body and fundic portions of the stomach. These cells secrete pepsinogen, from which the proteolytic (protein-digesting) enzyme pepsin is formed.

What are chief cells and parietal cells?

Chief cells produce pepsinogen, which is converted to pepsin by hydrochloric acid in the stomach. Parietal cells produce hydrochloric acid, allowing this conversion. Goblet cells produce the mucous lining of the stomach that protects the stomach epithelium from damage from the acidic environment of the gastric lumen.

Where are gastric chief cells?

Anatomy. In mammals, chief cells are located at the base of glands distributed throughout the fundus and corpus of the stomach. It is thought that chief cells derive from mucous neck cells located in the midportion of the glands.

What do chief cells secrete and what is the function?

Chief cells are the other type of exocrine secretory cell in the stomach. They secrete digestive enzymes that cleave the proteins in food into smaller pieces. Pepsin is secreted as an inactive enzyme called pepsinogen which is secreted by the chief cell.

Are C cells the same as chief cells?

The chief cells are much more prevalent in the parathyroid gland than the oxyphil cells. It is perceived that oxyphil cells may be derived from chief cells at puberty, as they are not present at birth like chief cells.

Parathyroid chief cell
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Anatomical terms of microanatomy

What kind of cells are chief cells?

In human anatomy, there are three types of chief cells, the gastric chief cell, the parathyroid chief cell, and the type 1 chief cells found in the carotid body.

Do chief cells produce gastric lipase?

Human gastric lipase is produced by chief cells and is colocated with pepsin.

What is the function of chief cells quizlet?

Chief cells secrete Gastric Lipase which functions to break down fats into smaller fatty acids that can be further digested in the intestine.

Which is the characteristic of chief cells?

Chief cells are responsible for secreting pepsinogen. They have basally located nuclei and a basophilic cytoplasm with abundant rough endoplasmic reticulum and many secretory granules that contain pepsinogen. These are secreted into the lumen of the gastric gland.

What are 4 cells of the stomach and their function?

Four major types of secretory epithelial cells cover the surface of the stomach and extend down into gastric pits and glands: Mucous cells: secrete an alkaline mucus that protects the epithelium against shear stress and acid. Parietal cells: secrete hydrochloric acid. Chief cells: secrete pepsin, a proteolytic enzyme.

What are the secretions of the chief cells and parietal cells quizlet?

Explanation. Chief cells secrete digestive enzymes, while parietal cells secrete a solution containing hydrochloric acid.

What are the three cell types of the gastric glands and what does each of them secrete quizlet?

Glandular mucous cells secrete mucus, the chief cells secrete enzymes, mainly pepsinogen, and the parietal cells produce hydrochloric acid and the intrinsic factor.

What controls gastric juice secretion?

Gastric acid secretion is regulated by three local hormones: acetylcholine, gastrin, and histamine. Of these three, acetylcholine has the largest effect. Parietal cells, G cells, and enterochromaffin-like cells are stimulated by acetylcholine released in response to vagus nerve simulation.

What is the role of parietal cells in the stomach?

Parietal cells are responsible for gastric acid secretion, which aids in the digestion of food, absorption of minerals, and control of harmful bacteria.

What will happen if parietal cells of gastric gland is blocked?

Hence, if the secretion of parietal cells of the gastric gland is blocked with an inhibitor, then pepsinogen won’t be converted into active pepsin and protein digestion will be affected. Hence, the correct option is In the absence of HCI secretion, inactive pepsinogen is not converted into the active enzyme pepsin.

What would happen if parietal cells stopped working?

Parietal glands also secrete pepsinogen to which hydrochloric acid acts to convert it into pepsin. Pepsin in return causes digestion of protein. If parietal cells become non-functional it will directly affect protein digestion.

What stimulates parietal cells?

Parietal cells are stimulated directly and indirectly by neural (acetylcholine), endocrine (gastrin), and paracrine (histamine) mechanisms.