What are atherogenic lipids?

Atherogenic lipids, particularly oxidized low-density lipoprotein, are responsible for a wide range of cellular dysfunctions within the vessel wall.

What does atherogenic lipid profile mean?

Atherogenic lipid profile or hyperlipidemia was defined as hypercholesterolemia (> or = 240 mg/dl) or high low-density lipoprotein cholesterol (high-LDLc > or = 160 mg/dl) or high lipoprotein (a) [high-Lp (a) > or =25 mg/dl], and low-BMD as t-score <-1 SD at lumbar o femoral site.

What is an atherogenic?

(II) Atherogenesis is a local (patchy) growth of cells and accumulation of lipids within the arterial wall consisting of a progression from microscopic foci, to fatty streaks, to raised plaques that become fibrous and calcified.

What is atherogenic cholesterol?

Atherogenic dyslipidemia (AD) refers to elevated levels of triglycerides (TG) and small-dense low-density lipoprotein and low levels of high-density lipoprotein cholesterol (HDL-C).

Why is lipoprotein A atherogenic?

Lipoprotein(a) has prothrombotic properties through its interference with reactions in fibrinolysis regulation, due to its antifibrinolytic role [46. Lipoprotein(a) as an old and new causal risk factor of atherosclerotic cardiovascular disease.

Is LP A atherogenic?

On an equimolar basis, Lp(a) is considered more atherogenic than LDL due to the presence of phosphocholine containing oxidized phospholipids (OxPLs) bound to apo(a).

Is lipoprotein A atherogenic?

It is now known that remnant lipoproteins containing apo C-III are highly atherogenic, as is lipoprotein(a) [Lp(a)], another member of the apo B-100 group. This article reviews recent studies involving LDL subclasses and atherogenic lipoproteins, many of which used novel methods of lipoprotein subfractioning.

Where is lipoprotein A found?

Lipoprotein (a) is synthesized in the liver and its plasma concentration, which can be determined by use of monoclonal antibody-based methods, ranges from < 1 mg to > 1,000 mg/dL. Lipoprotein (a) levels over 20-30 mg/dL are associated with a two-fold risk of developing coronary artery disease.

What is lipoprotein A and what does it mean for you?

Lipoprotein (a) is a type of LDL (bad) cholesterol. A high level of lipoprotein (a) may mean you are at risk for heart disease. Other names: cholesterol Lp(a), Lp(a)

What are transport vehicles for most lipids called?

Because lipids are insoluble in water, they require a special transport vehicle to move through the body’s bloodstream. These transport vehicles are called lipoproteins.

What is the function of LP A?

The physiological functions of Lp(a) include wound healing, promoting tissue repair and vascular remodeling.

What is the difference between lipoprotein A and LDL?

Lipoproteins are made of protein and fat. They carry cholesterol through your blood. Lp(a) is a type of low-density lipoprotein (LDL). LDL is known as “bad” cholesterol.

What is LPA gene?

LPA (Lipoprotein(A)) is a Protein Coding gene. Diseases associated with LPA include Lipoprotein Quantitative Trait Locus and Familial Hyperlipidemia. Among its related pathways are Metabolism and Lipoprotein metabolism.

What does VLDL stand for?

Very-low-density lipoprotein (VLDL) cholesterol is produced in the liver and released into the bloodstream to supply body tissues with a type of fat (triglycerides).

Where do chylomicrons go?

Nearly all dietary lipid is transported in chylomicrons from the gut to the blood through the lymphatic system by entering specialized lymphatic vessels, referred to as lacteals, in the villi of the intestine (Fig. 1).

Which is worse LDL or VLDL?

LDL is considered ‘bad’ cholesterol because high levels can lead to the buildup of plaque in your arteries,” said Chiadika. “VLDL is considered ‘bad’ cholesterol as well but it mainly carries triglycerides, the most common type of fat in your body.

Where are LDL made?

the liver

But they are made by the liver. As the body’s cells extract fatty acids from VLDLs, the particles turn into intermediate density lipoproteins, and, with further extraction, into LDL particles.

Where are chylomicrons made?

intestinal cells

Chylomicrons are made only in intestinal cells, whereas VLDLs are also synthesized in the liver. To form a chylomicron, triglycerides, fat-soluble vitamins, and cholesterol are coated with a layer of apolipoprotein (apo A and B types),77 cholesterol ester, and phospholipids.

What does HDL stand for?

HDL (high-density lipoprotein), or “good” cholesterol, absorbs cholesterol and carries it back to the liver. The liver then flushes it from the body. High levels of HDL cholesterol can lower your risk for heart disease and stroke.

Does the liver make LDL?

Your liver makes all the cholesterol your body needs. Cholesterol and other fats are carried in your bloodstream as spherical particles called lipoproteins. The two most commonly known lipoproteins are low-density lipoproteins (LDL) and high-density lipoproteins (HDL).

Is LFT and lipid profile same?

The results obtained for the 100 patients studied gave a very good correlation between lipid profile and all the Liver Function Tests as well as to HbA1c, confirming that lipid profile analytes are indeed associated with liver function tests as well as to glycosylated hemoglobin.

What is the difference between cholesterol and fat?

Cholesterol is a type of lipid, just as fats are. However, unlike fat, cholesterol can’t be exercised off, sweated out or burned for energy. It is found only in animal products, including meat, chicken, fish, eggs, organ meats and high-fat dairy products.

Can high triglycerides cause liver problems?

Triglycerides and Your Liver

So you know that your liver makes triglycerides, but when levels are severely high—like around 2,000 mg/dL—it can also lead to harmful fat buildup in the liver, or fatty-liver disease, according to Harvard Health.

Can a fatty liver cause high triglycerides?

High triglyceride levels can be a clue that you have fatty liver disease. Poor eating habits lead not only to high levels of fat in the bloodstream (triglycerides) but increased storage of fat throughout the body, including in the liver.

What organ controls triglycerides?

The liver

The liver is the central organ that controls lipid homeostasis by means of complex, but precisely regulated biochemical, signaling and cellular pathways. Hepatocytes are the main liver parenchymal cells, which control hepatic biochemical and metabolic functions in the liver, including triglyceride metabolism.