Is Metolazone an ACE inhibitor?


What class of drug is metolazone?

Metolazone is in a class of medications called diuretics (‘water pills’). It causes the kidneys to reduce the amount of water and salt in the body by increasing the amount of urine.

What is the difference between metolazone and furosemide?

Lasix (furosemide) and Zaroxolyn (metolazone) are diuretics (water pills) used treat excess accumulation of fluid or swelling of the body (edema) and high blood pressure (hypertension). Lasix is a brand name for furosemide. Zaroxolyn is a brand name for metolazone.

What is the difference between hydrochlorothiazide and metolazone?

Metolazone is more potent than hydrochlorothiazide and retains its effectiveness even when there is severe glomerular filtration rate (GFR) reduction. Diuretics are used to achieve and maintain euvolaemia (the patient’s ‘dry weight’) with the lowest possible dose.

Is metolazone a strong diuretic?

Even at low doses metolazone significantly potentiates the diuretic effects of furosemide and therefore simplifies the treatment of fluid retention. High doses of furosemide can be avoided in many cases, a factor of particular advantage in ambulatory long term therapy and in patients with decreased kidney function.

Why do you give metolazone 30 minutes before furosemide?

Many physicians dose metolazone 30 minutes prior to dosing the loop diuretic to ensure the distal Na-Cl channel is already blocked when the increased sodium reaches the DCT.

Can you give metolazone and Lasix together?

You may need dose adjustments or special tests in order to safely take both medications together. This combination may lower levels of certain minerals in your body such as potassium, magnesium, and sodium.

Is metolazone a vasodilator?

Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess fluid accumulation in heart failure.
Metolazone.

Clinical data
UNII TZ7V40X7VX
KEGG D00431
ChEBI CHEBI:64354
ChEMBL ChEMBL878

Is metolazone a thiazide diuretic?

High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled . Metolazone is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps to lower blood pressure .

What time of day should you take metolazone?

It is best to take this medication at least 4 hours before your bedtime. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day as directed. Keep taking this medication even if you feel well.

Can you take metolazone every day?

Do not use this medicine in larger or smaller amounts or for longer than recommended. Metolazone is usually taken only once per day. You may need to limit salt in your diet while taking this medicine. Follow your doctor’s instructions carefully.

Do you need potassium with metolazone?

Which drugs or supplements interact with metolazone? Metolazone can reduce blood potassium and magnesium levels. This is especially true in patients who also are taking “loop” diuretics such as furosemide (Lasix), bumetanide (Bumex), and torsemide (Demadex ).

Does metolazone increase potassium?

Although metolazone does not have the same structure as the other thiazide diuretics, it increases the excretion of sodium, potassium, and water by inhibiting sodium reabsorption in the distal and proximal convoluted tubule.

What is the best diuretic for congestive heart failure?

Loop diuretics remain the diuretic of choice for treating patients with heart failure. Furosemide, torsemide and bumetanide are the agents widely available for clinical use, with furosemide the predominant agent of the three.

Does metolazone affect blood sugar?

Metolazone can cause changes to your electrolyte levels, which may bring on a hepatic coma in people with liver disease. For people with diabetes: Metolazone can increase your blood sugar level. Talk to your doctor before using this drug if you have diabetes.

Can metolazone increase creatinine?

Initial treatment produced small increases in serum creatinine among patients with renal insufficiency, suggesting that GFR was decreased secondary to diuresis-induced volume depletion. The study demonstrates that metolazone is both safe and effective over long periods of time.

Can metolazone use in renal failure?

[7] demonstrated that high-dose metolazone use in chronic renal failure, in daily doses ranging from 20 to 150 mg, achieved a 51 % increase in mean urine flow rate and a 113 % increase in mean sodium excretion, with no reported side effects in their study on 14 subjects.

Can metolazone cause muscle spasms?

Musculoskeletal cramps are associated with metolazone therapy, as with other diuretics, and may be associated with electrolyte disorders and rapid intravascular volume shifts.

Does metolazone cause insomnia?

Syncope, neuropathy, vertigo, paresthesias, psychotic depression, impotence, dizziness/lightheadedness, drowsiness, fatigue, weakness, restlessness (sometimes resulting in insomnia), headache.

How often can you take metolazone?

For oral dosage form (tablets): For fluid retention (edema): Adults—At first, 5 to 20 milligrams (mg) once a day. Your doctor may adjust your dose if needed.

Can metolazone cause pancreatitis?

Metolazone-induced acute pancreatitis and hypercalcemia are described in a 58-year-old woman with severe congestive cardiac failure. Her symptoms and laboratory abnormalities rapidly resolved upon discontinuation of metolazone.