The Diamond Blackfan Anemia Registry (DBAR) reported 73% survival for matched sibling donors at 5 years, compared with 17% for unrelated donors. Results were best for patients transplanted at less than 10 years of age without significant iron overload.
- 1 Is Diamond-Blackfan anemia fatal?
- 2 Is Diamond-Blackfan anemia rare?
- 3 How does Diamond-Blackfan anemia affect the body?
- 4 Who is most likely to get Diamond-Blackfan anemia?
- 5 Is there a treatment for Diamond-Blackfan anemia?
- 6 How do people get Diamond-Blackfan anemia?
- 7 What is the best treatment for aplastic anemia?
Is Diamond-Blackfan anemia fatal?
First described in 1938 by Boston Children’s Hospital doctors Kenneth Blackfan, MD, and Louis Diamond, MD (who later established Dana-Farber/Boston Children’s Cancer and Blood Disorders Center), DBA is a potentially life-threatening condition that can cause severe anemia and other abnormalities.
Is Diamond-Blackfan anemia rare?
Diamond Blackfan anemia (DBA) is a rare blood disorder that affects the bone marrow.
How does Diamond-Blackfan anemia affect the body?
In Diamond-Blackfan anemia, the bone marrow malfunctions and fails to make enough red blood cells, which carry oxygen to the body’s tissues. The resulting shortage of red blood cells (anemia ) usually becomes apparent during the first year of life.
Who is most likely to get Diamond-Blackfan anemia?
Facts about Diamond Blackfan Anemia
DBA affects about seven in every 1 million babies. Boys and girls of all races are equally affected. Most of the time, signs or symptoms of anemia appear by 2 months of age, and the diagnosis of DBA is usually made in the first year of life. DBA may be passed down through families.
Is there a treatment for Diamond-Blackfan anemia?
Bone marrow transplant is the only treatment that is curative for Diamond-Blackfan anemia. Compatible means that the donor has the same types of proteins, called human leukocyte antigens (HLA), on the surface of their cells as the person with Diamond-Blackfan anemia who will be receiving the transplant.
How do people get Diamond-Blackfan anemia?
Diamond-Blackfan anemia, also known as acquired pure red cell aplasia, is usually diagnosed when a child is less than a year old. It’s caused by changes, or mutations, in their genes, which are the building blocks of DNA. Sometimes the genetic mutation is passed down from one parent to a child.
What is the best treatment for aplastic anemia?
A bone marrow transplant is the only cure for aplastic anemia. Bone marrow transplants are also called stem cell transplants. A transplant is the preferred treatment for severe aplastic anemia. Bone marrow transplants replace damaged stem cells with healthy ones.