Diagnosis. Diagnosis of vaso-occlusive crisis is based on clinical manifestations, complete blood count with white blood cell differential, platelet count, reticulocyte count, and comprehensive metabolic panel with liver and kidney function tests.
- 1 How is sickle cell crisis diagnosed?
- 2 Is vaso-occlusive crisis a medical diagnosis?
- 3 What labs confirm sickle cell crisis?
- 4 What does a vaso-occlusive crisis feel like?
- 5 What are the clinical signs and symptoms of vaso-occlusive disorders?
- 6 Which manifestations of Vasoocclusive crisis are associated with sickle cell disease SCD in infants?
- 7 What is a major symptom of vaso-occlusive crisis in sickle cell anemia?
- 8 What can cause vaso-occlusive crisis?
- 9 Does vaso-occlusive crisis cause hematuria?
- 10 What are the symptoms of glomerulonephritis?
- 11 How does sickle cell anemia cause polyuria?
- 12 Where is the renal medulla?
- 13 Which finding supports the diagnosis of condyloma Acuminatum?
- 14 What is the easiest way to distinguish the kidney cortex from the medulla?
How is sickle cell crisis diagnosed?
Sickle cell anemia is usually diagnosed through genetic screening done when a baby is born. Those test results will likely be given to your family doctor or pediatrician. He or she will likely refer you to a doctor who specializes in blood disorders (hematologist) or a pediatric hematologist.
Is vaso-occlusive crisis a medical diagnosis?
VOCs can be extremely painful and are considered a medical emergency. Short-term or acute management largely focuses on controlling pain with pain-relieving medications (analgesics). Opioids are commonly used for this purpose.
What labs confirm sickle cell crisis?
Which lab tests are performed in with the workup of sickle cell disease (SCD)?
- Mandatory screening for HbS at birth in the United States; prenatal testing can be obtained via chorionic villus sampling.
- Hemoglobin electrophoresis.
- CBC count with differential and reticulocyte count.
- Serum electrolytes.
What does a vaso-occlusive crisis feel like?
When these stiff, misshaped cells get stuck and block small blood vessels, depriving tissues and organs of oxygen-rich blood, it can lead to what’s called a vaso-occlusive crisis. This crisis causes severe pain and fatigue, Pittman says, and can lead to organ failure, stroke and other problems.
What are the clinical signs and symptoms of vaso-occlusive disorders?
You may also have:
- Breathing problems (shortness of breath or pain when breathing or both)
- Extreme tiredness.
- Headache or dizziness.
- Painful erections in males.
- Weakness or a hard time moving some parts of your body.
- Yellowish skin color (jaundice)
Which manifestations of Vasoocclusive crisis are associated with sickle cell disease SCD in infants?
This sudden pain can happen anywhere, but most often occurs in the chest, arms, and legs. Babies and young children may have painful finger and toe swelling. Blocked blood flow may also cause tissue death.
What is a major symptom of vaso-occlusive crisis in sickle cell anemia?
Pain Patterns in the Vaso-occlusive Crisis
A vaso-occlusive crisis most commonly involves the back, legs, knees, arms, chest and abdomen. 4,5,12 The pain generally affects two or more sites. Bone pain tends to be bilateral and symmetric. Recurrent crises in an individual patient usually have the same distribution.
What can cause vaso-occlusive crisis?
Triggers of vaso-occlusive crisis include the following:
- Hypoxemia: May be due to acute chest syndrome or respiratory complications.
- Dehydration: Acidosis results in a shift of the oxygen dissociation curve.
- Changes in body temperature (eg, an increase due to fever or a decrease due to environmental temperature change)
Does vaso-occlusive crisis cause hematuria?
The vaso-occlusive process causes decreased blood flow in the renal medulla and results in medullary hypoxia, ischemia, necrosis and hematuria.
What are the symptoms of glomerulonephritis?
What are the symptoms of glomerulonephritis?
- High blood pressure.
- Swelling of the face, hands, feet, and belly.
- Blood and protein in the urine (hematuria and proteinuria)
- Decreased urine output.
How does sickle cell anemia cause polyuria?
Tubular dysfunction and hemodynamic changes in sickle cell nephropathy. Urinary concentrating defect is the most common tubular dysfunction in SCD. Inability to concentrate urine leads to polyuria, nocturnal enuresis and increased risk for dehydration in children.
Where is the renal medulla?
The renal medulla is the innermost part of the kidney. The renal medulla is split up into a number of sections, known as the renal pyramids. Blood enters into the kidney via the renal artery, which then splits up to form the segmental arteries which then branch to form interlobar arteries.
Which finding supports the diagnosis of condyloma Acuminatum?
Condyloma acuminatum, commonly called anogenital warts, are typically diagnosed clinically, using visual examination, sometimes aided by a magnifying glass. Patients or clinicians may notice lesions, which may be on anogenital skin or mucous membranes.
What is the easiest way to distinguish the kidney cortex from the medulla?
The main difference between renal cortex and renal medulla is that renal cortex is the outer region of the kidney which contains blood vessels connected to the nephrons whereas renal medulla is the inner region of the kidney which contains 8-12 renal pyramids.