How is Activase administered?

Activase is for intravenous administration only. Extravasation of Activase infusion can cause ecchymosis or inflammation. If extravasation occurs, terminate the infusion at that IV site and apply local therapy.

How do nurses administer tPA?

Administration

  1. Maximum recommended dose is 90mg.
  2. Patients less than or equal to 100 kg load with 0.09 mg/kg (10% of 0.9 mg/kg dose) as an IV bolus over 1 minute, followed by 0.81 mg/kg (90% of 0.9 mg/kg dose) as a continuous infusion over 60 minutes.

How is IV alteplase administered?

Alteplase is administered intravenously at a concentration of 1 mg/mL for the treatment of acute ischemic stroke, pulmonary embolism, and myocardial infarction. The reconstituted solution is stable for 8 hours at room temperature.

How is tissue plasminogen activator administered?

A tPA is administered through an IV with treatment lasting about one hour. Patients are monitored closely throughout the process, and about 55% of patients who receive a tPA are more likely to go home following treatment.

How do you administer alteplase injection?


The two vials. So the vial of activase is on the bottom and the sterile water for injection is on top allow the entire contents of the sterile.

How is Activase administered for AIS?

Activase is for intravenous (IV) administration only. Extravasation of Activase infusion can cause ecchymosis or inflammation. If extravasation occurs, terminate the infusion at that IV site and apply local therapy. Administer Activase as soon as possible after the onset of symptoms.

How are thrombolytics administered?

The “clot-busting” drug will be delivered through a peripheral intravenous (IV) line, usually through a visible vein in your arm. Performed at your bedside in an intensive care unit while your heart and lung functions are monitored. The drug circulates within the blood stream until it reaches the clot.

How do you administer Cathflo Activase?

Inject the 2.2 mL of Sterile Water for Injection, USP, into the Cathflo Activase vial, directing the diluent stream into the powder. Slight foaming is not unusual; let the vial stand undisturbed to allow large bubbles to dissipate. Mix by gently swirling until the contents are completely dissolved.

How do you mix Activase?

Quote from Youtube:
Device into the vial containing activase a process that requires approximately two minutes about half a milliliter of sterile water may remain in the upper.

What is the window for administering tPA?

IV tPA should be administered to all eligible acute stroke patients within 3 hours of last known normal and to a more selective group of eligible acute stroke patients (based on ECASS III exclusion criteria) within 4.5 hours of last known normal.

What do you reconstitute Activase with?

Follow the steps below for reconstituting 100-mg vials. Reconstitute Activase immediately before administration, using only preservative free Sterile Water for Injection (SWFI), U.S. Pharmacopeia (USP) and the transfer device.

What is tPA administration?

Tissue plasminogen Activator (tPA) is used to treat stroke in its early stages. The medication is a protein that activates enzymes to break down blood clots, helping to restore blood flow to the brain during an acute ischemic stroke. IV administration of tPA is the gold-standard treatment for stroke.

How do I give a port to tPA?

Using a gentle push and pull technique, alteplase is instilled into the port. A small amount (between 0.1 mL and 0.2 mL) of alteplase in the port is enough to start lysis and allow additional space for instillation of alteplase to a total dose of 2 mg (Figure 5).