Do CEA levels fluctuate?

Serum CEA levels fluctuate over time in healthy individuals, and the intraindividual variation has been reported to be about 30% [19].

Why does CEA go up and down?

Carcinoembryonic Antigen, also called CEA, is a protein that may be elevated in many colorectal cancer patients and is detected in the blood. CEA levels are expected to go down in patients who have had surgery to remove their tumor. An elevated CEA may indicate a recurrence of your cancer.

Why did my CEA go up?

A high level of CEA can be a sign of certain types of cancers. These include cancers of the colon and rectum, prostate, ovary, lung, thyroid, or liver. High CEA levels may also be a sign of some noncancerous conditions, such as cirrhosis, noncancerous breast disease, and emphysema.

How fast does CEA increase?

Two distinct patterns of CEA rise were observed: a ‘fast’ rise in which serum concentrations reached 100 microgram/l within 6 months of the first elevation and a ‘slow’ rise in which concentrations remained less than 75 microgram/l for at least 12 months.

How long does it take for CEA to return to normal?

After successful surgical resection of colorectal cancer, an increased CEA concentration should return to normal within 4 to 6 weeks. Failure of an increased preoperative level to decrease in to the normal range within 6 weeks of surgery frequently is associated with recurrent disease.

What can falsely elevated CEA?

Diabetes, smoking, chronic obstructive pulmonary disease, and colonic polyps were considered as causes of false elevation. The false-positive rates of CEA according to level were as follows: 5.1–10.0 ng/mL, 99.5%; 10.1–15.0 ng/mL, 87.2%; 15.1–20.0 ng/mL, 100.0%; >20.0 ng/mL, 33.3%.

How long does it take for CEA levels to go down?

A normal level of CEA is less than or equal to 3 nanograms per milliliter (ng/mL). Most healthy people have levels below this amount. CEA levels will generally return to normal between one and four months after the cancer has been successfully removed.

Does Covid increase CEA levels?

SARS-CoV-2 infection might be another cause of CEA elevation, with nearly 20% of patients experienced transient and marked CEA increment during COVID-19 pneumonia. The false-positive results of CEA elevation might have clinical significance for patients with colorectal cancer.

How do I lower my CEA levels?

Thus, we suggest that exercise for 2-3 days per week decreases the expression of CEA and improves body condition, without loading fatigue or stress, which may contribute to preventing cancer in the elderly women.

How accurate is CEA blood test?

Sensitivity of CEA ranged from 17.4 % to 100 %, specificity ranged from 66.1 % to 98.4 %, positive predictive value ranged from 45.8 % to 95.2% and negative predictive value ranged from 74.5 % to 100 %.

What does a CEA level of 8 mean?

A CEA value of greater than 8 ng/ml was highly suggestive of residual disease or recurrence, even when no clinical evidence was present. Approximately 90% of the patients dying from colorectal cancer showed an increase in CEA to greater than 8 ng/ml during the course of the disease.

How often should CEA test be done?

The National Comprehensive Cancer Network, for example, recommends that people who are treated for stage II or III colon or rectal cancer have CEA testing every 3 to 6 months for 2 years and then every 6 months for 3 additional years, plus CT scans every 6 to 12 months for 5 years.

What is a CEA flare?

For the study, a CEA flare was defined as a ≥ 15% rise from baseline (at least 4 ug/L), followed by a subsequent ≥ 15% decrease from baseline in CEA level within four to six weeks of initial treatment.

How long does a CEA flare last?

The median duration of CEA flare (from date of baseline CEA to date of first CEA level below the baseline) was 49 days (range 16–117 days).

What does a CEA level of 7 mean?

The normal range for CEA is 0 to 2.5 nanograms per milliliter of blood (ng/mL). If CEA levels remain elevated during treatment, your treatment may not have been as successful as hoped. Anything greater than 10 ng/mL suggests extensive disease, and levels greater than 20 ng/mL suggest the cancer may be spreading.

Does Chemo reduce CEA levels?

After three cycles of chemotherapy, serum CEA and CA 19-9 levels were re-measured. CEA levels decreased, were maintained, or increased by <20% versus baseline in 33 patients, and increased by >20% in 15. CA 19-9 levels decreased, were maintained, or increased by <20% in 39 patients, and increased by >20% in 9.

Can CEA rise after chemo?

An initial rise of CEA during chemotherapy in colorectal cancer patients may therefore not always indicate progression of disease but may be a transient CEA surge in patients responding to chemotherapy.

Does CEA go up after chemo?

The transient CEA increase usually started between 2-4 cycles and resolved 1-2 months following completion of chemotherapy. 6 out of 38 patients with rising CEA underwent scans during and following chemotherapy which did not show disease recurrence or metastases.

Can chemo cause CEA to rise?

Conclusion: CEA or CA19-9 surges can be observed in MRGC patients receiving chemotherapy. All patients with these surge phenomena had clinical benefits from chemotherapy. An initial rise in CEA or CA19-9 levels after initiation of chemotherapy should not be used as an indicator of progressive disease.